Comment on Keeping Up With Science : InTech Publishes 49 New Books For You To Get Hold Of Right Now by sandipniauskas

Comment on Keeping Up With Science : InTech Publishes 49 New Books For You To Get Hold Of Right Now by sandipniauskas:

Thanks on behalf of our ovarian cancer communities, families and friends for your book on Ovarian Cancer and in particular the section by Dr Yi Pan (neuropathy). Yi is a favourite and does so very much for many patients.

free book: Ovarian Cancer - Clinical and Therapeutic Perspectives | InTechOpen (includes the chapter on neuropathy by Dr Yi Pan)

free book: Ovarian Cancer - Clinical and Therapeutic Perspectives - InTechOpen

open access: Peripheral Neuropathy In Ovarian Cancer | InTechOpen (pdf file) - should be a priority read

Blogger's Note: should be a priority reading:
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Peripheral Neuropathy in Ovarian Cancer  

Yi Pan

Source: Ovarian Cancer - Clinical and Therapeutic Perspectives
ISBN 978-953-307-810-6
Edited by: Samir Farghaly
Publisher: InTech, February 2012

Download PDF

Peripheral Neuropathy in Ovarian Cancer

(Dr.) Yi Pan
Department of Neurology & Psychiatry, Saint Louis University
USA

1. Introduction

Peripheral neuropathy is not uncommon in ovarian cancer. The incidence density of peripheral neuropathy was 21.5 per 1000 person-years in ovarian cancer, 15.3 per 1000 person-years in breast cancer and 18.3 per 1000 person-years in lung cancer for patients who
received platinum-taxane combination chemotherapy (Nurgalieva et al., 2010).

Carboplatin/paclitaxel is the chemotherapy of choice for advanced ovarian cancer, which has been reported to associate with chemotherapy induced neurotoxicity in as high as 54% of patients after their first-line 6 cycles of treatment and with 23% of patients with residual neuropathy after a median follow up of 18 months (Pignata et al., 2006 ).

However, peripheral neuropathy in ovarian cancer is not always due to chemotherapeutic agents. Other etiologies of neuropathy in ovarian cancer patients are focal compression, nutritional
deficiency, ......cont'd


5. Conclusion

Peripheral neuropathy in ovarian cancer is complex. When patients develop neuropathy symptoms in ovarian cancer, we cannot simply conclude that it is chemotherapy-induce neuropathy. It is a challenge to treat this condition. Diagnosis of the etiology of the neuropathy, treating the underlying disease, correction of metabolic, nutritional, endocrine abnormalities, and decompression of the nerve entrapment will preserve nerve function. The goals of treatment are reduction of symptoms, improvement of function and patient’s quality of life.

selected photos (ovarian cancer survivor participants)

Dr Yi Pan

UK artists Clare and Denise

Participant displays event poster

young participants

Participants

Endometrioid ovarian carcinoma benefits from aromatase inhibitors: case report and literature review (abstract) Dr Yi Pan (author)

(case report/review) Conclusions Endometrioid ovarian carcinoma may benefit from aromatase inhibitors, especially when the tumour burden is low after primary chemotherapy or when the inhibitor is used as maintenance therapy between chemotherapies.