low-grade serous ovarian cancer part of the tumor spectrum of Hereditary Breast and Ovarian Cancer?

Research Highlights

► Low-grade ovarian cancer patients have less family history of breast/ovarian cancer.
► Ovarian cancer grade may be an important factor in hereditary cancer risk assessment.
► Offer BRCA testing to patients with strong family history, regardless of tumor grade.

abstract: Genetic profiles distinguish different types of hereditary ovarian cancer

"The results indicate that HBOC and HNPCC (Lynch Syndrome) associated ovarian cancer develop along distinct genetic pathways and genetic profiles can thus be applied to distinguish between different types of hereditary ovarian cancer."

clinical trial: Attitudes About Childbearing And Fertility With Inherited Breast And Ovarian Cancer Syndromes (HBOC) - Full Text View - ClinicalTrials.gov

Purpose

Objectives:

- To evaluate the attitudes and opinions of women undergoing genetic counseling for hereditary breast and ovarian cancer syndrome, both before and after testing, in regards to pregnancy and fertility

Pre-counseling Education for Low Literacy Women at Risk of Hereditary Breast and Ovarian Cancer (HBOC): Patient Experiences Using the Cancer Risk...

Pre-counseling Education for Low Literacy Women at Risk of Hereditary Breast and Ovarian Cancer (HBOC): Patient Experiences Using the Cancer Risk Education Intervention Tool (CREdIT)

A High Proportion of DNA Variants of BRCA1 and BRCA2 Is Associated with Aberrant Splicing in Breast/Ovarian Cancer Patients

Conclusions: An important fraction of DNA variants of BRCA1/2 presents splicing aberrations that may represent a relevant disease-causing mechanism in HBOC.