recruiting: The Molecular Predisposition to (Lynch Syndrome) (HNPCC) - ClinicalTrials.gov - see Blogger's Notes on this trial

Blogger's Note:  

this trial does not include a spectrum of Lynch Syndrome-associated cancers such as; ovarian, brain, pancreatic - all high mortality rate cancers except research indicates that those with genetic syndromes (in general) have improved survival rates; there may be a connection as to what and what has not been included (cancer sites) as this is a 15 yr observational study; however, if interested in participating, the contact information is below; it would be interesting to understand the (exclusion by default) inclusion rationale and in particular relating to those of the  rarer cancer sites in Lynch Syndrome
    ~~~~~~~~~~~~~~~~~~~~~~~~

The Molecular Predisposition to Hereditary Nonpolyposis Colon Cancer (HNPCC)

This study is currently recruiting participants.

Verified December 2011 by M.D. Anderson Cancer Center

First Received on October 4, 2011. Last Updated on December 20, 2011 History of Changes

Please refer to this study by its ClinicalTrials.gov identifier: NCT01447199

Contact: Patrick Lynch, MD, JD

713-794-5073

Purpose

The goal of this study is to understand factors which may influence risk for colorectal and other cancers in families. These factors include genetic variability, in combination with diet and lifestyle. In order to achieve these goals, the investigators need to contact as many eligible participants as possible.

This study proposes to identify genetic risk factors that predispose to colorectal cancer (CRC). The focus of this study will be to understand the role of the mismatch repair genes responsible for Hereditary Non-polyposis Colorectal Cancer (HNPCC), i.e., hMSH2, hMLH1 and other mismatch repair genes and modifier genes in combination with diet and lifestyle in familial and de novo colon cancer cases. By examining the status of the mismatch repair genes in both normal and neoplastic tissues among mismatch repair gene mutation carriers, family members not carrying the mutation and non-HNPCC families, it will be possible to determine the role of the mismatch repair genes in the development of colon cancer within HNPCC families.

Condition	Intervention
Bladder Cancer Colorectal Cancer Endometrial Cancer Kidney Cancer Skin Cancer Uterus Cancer	Behavioral: Health and Diet Questionnaire

ongoing clinical trial: Women Who Are At Risk Or May Have Lynch Syndrome - Full Text View - ClinicalTrials.gov