Preneoplasias of ovarian carcinoma : Biological and clinical aspects of different pathways of tumorigenesis

abstract- Gynecologic Oncology : Comparison of candidate serologic markers for type I and type II ovarian cancer

Objective

To examine the value of individual and combinations of ovarian cancer associated blood biomarkers for the discrimination between plasma of patients with type I or II ovarian cancer and disease-free volunteers.

Research highlights

► We compared 14 biomarkers to discriminate the plasma samples of healthy volunteers and ovarian cancer patients.
► Autoantibodies to p53 and NY-ESO-1 were present in plasma of type II but not type I ovarian cancer patients.
► Combining p53 AAbs with CA125 significantly improved discrimination of plasma of type II cancer patients from that of healthy volunteers.