free full access paper + video: Effect of Screening on Ovarian Cancer Mortality, June 8, 2011 JAMA The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Randomized Controlled Trial

also:

JAMA Report Video This JAMA Report summarizes key findings from the article in video format and includes an interview with one of the authors.

The video script and links to the video are available at http://pubs.ama-assn.org/media/2011jer/0604.dtl#vnrscript

JAMA REPORT (VIDEO SCRIPT)

 

  VIDEO: Windows Media | Quicktime
   YEARLY OVARIAN CANCER SCREENING ASSOCIATED WITH NO REDUCTION IN DEATH AND INCREASED FALSE POSITIVE TESTS

Pathologic findings following false-positive screening tests for ovarian cancer in the Prostate, Lung, Colorectal and Ovarian (PLCO) cancer screening

Abstract

OBJECTIVE: In the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial (PLCO), ovarian cancer screening with transvaginal ultrasound (TVU) and CA-125 produced a large number of false-positive tests. We examined relationships between histopathologic diagnoses, false-positive test group, and participant and screening test characteristics.

CONCLUSIONS: False-positive ovarian cancer screening tests were associated with a range of histopathologic diagnoses, some of which may be related to patient and screening test characteristics. Further research into the predictors of false-positive ovarian cancer screening tests may aid efforts to reduce false-positive results.