OVARIAN CANCER and US: acetylcysteine

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Showing posts with label acetylcysteine. Show all posts
Showing posts with label acetylcysteine. Show all posts

Wednesday, March 30, 2011

EvidenceUpdates - Interventions for preventing neuropathy caused by cisplatin and related compounds



BACKGROUND:
Cisplatin and several related antineoplastic agents used to treat many types of solid tumors are neurotoxic, and most patients completing a full course of cisplatin chemotherapy develop a clinically detectable sensory neuropathy. Effective neuroprotective therapies have been sought.


AUTHORS' CONCLUSIONS:
At present, the data are insufficient to conclude that any of the purported chemoprotective agents (acetylcysteine, amifostine, calcium and magnesium, diethyldithiocarbamate, glutathione, Org 2766, oxycarbazepine, or Vitamin E) prevent or limit the neurotoxicity of platin drugs among human patients.