Showing posts with label array testing. Show all posts
Showing posts with label array testing. Show all posts
Wednesday, July 07, 2010
Testing for CHEK2 in the cancer genetics clinic: ready for prime time?
Abstract
Narod SA.
Testing for CHEK2 in the cancer genetics clinic: ready for prime time?
The 1100delC mutation of the CHEK2 gene was found to be a cause of breast cancer in 2002. The lifetime risk of breast cancer among women with a mutation and with a family history of breast cancer is approximately 25%. These women are good candidates for screening with MRI and for chemoprevention with tamoxifen. It is reasonable to test for this single mutation when women undergo testing for BRCA1 and BRCA2.
add your opinions
array testing
,
BRCA1
,
BRCA2
,
CHEK2
,
dynamic constrast mri
,
Tamoxifen
,
test
Wednesday, June 02, 2010
Functional Proteomic Analysis of Advanced Serous Ovarian Cancer Using Reverse Phase Protein Array: TGF-β Pathway Signaling Indicates Response to Primary chemotherapy
Abstract Purpose: Using reverse phase protein array, we measured protein expression associated with response to primary chemotherapy in patients with advanced-stage, high-grade serous ovarian cancer. Conclusion: TGF-β pathway signaling likely plays an important role as a marker or mediator of chemoresistance in advanced serous ovarian cancer. On this basis, future studies to develop and validate a useful predictor of treatment failure are warranted.
add your opinions
array testing
,
chemoresistance
,
inherited markers
,
protein
,
serous
,
TGF-B
A genomic and transcriptomic approach for a differential diagnosis between primary and secondary ovarian carcinomas in patients with a previous histor
CONCLUSIONS: In patients with ovarian carcinoma and a previous history of breast cancer, SNP array analysis can be used to distinguish primary and secondary ovarian tumors.
add your opinions
array testing
,
genetic testing
,
SNP
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