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Showing posts with label cancer genome. Show all posts
Showing posts with label cancer genome. Show all posts

Thursday, February 23, 2012

Cepmed Launches Online Personalized Medicine Portal for Canadians - media release



Cepmed Launches Online Personalized Medicine Portal: Media Release, Montreal

The Centre of Excellence in Personalized Medicine (Cepmed), announced today that they have launched a web-based Personalized Medicine Portal for Canadians and joined DNA Direct by Medco's Genomic Medicine Network (GMN).

Cepmed's Personalized Medicine Portal (Portal) provides information and decision making tools that will help patients understand how genetic testing can be used to inform treatment decisions and enable better communication between patients and providers. The Portal, available at www.cepmed.com, provides information about access to specific genetic tests in each Province. "Many of the stakeholders have told us that there is a dearth of reliable, evidence based information concerning personalized medicine tests. A centralized source of information about which tests exist, who should take them and how they should be interpreted is what we are offering through our partnership with DNA Direct by Medco. We believe this resource will contribute to improved patient outcomes and savings to the health care system." - Dr. Clarissa Desjardins - CEO, Cepmed.

According to the Personalized Medicine Coalition, there are more than 50 genetic tests currently available that can inform treatment decisions and drug therapy for a wide range of diseases.(i) With the availability of these tests, support and demand for personalized medicine is growing internationally. However, effective integration of personalized medicine into clinical care is challenging. It is widely thought that effective adoption of personalized medicine will require the participation of informed and engaged patients and healthcare providers.

Cepmed plans to use the Portal as a key element of implementation studies in personalized medicine, collaborating with healthcare providers, patient organizations and the public to define how personalized medicine is best applied within the Canadian health care system. These studies will be informed by Cepmed's participation in DNA Direct by Medco's GMN. The GMN brings together leaders in personalized medicine and offers opportunities to establish multi-site studies in genomics, with a particular focus on real-world or implementation studies.

"We are excited about this opportunity to expand our Genomic Medicine Network to include a premier personalized medicine organization in Canada," said Joan Kennedy, President of DNA Direct by Medco. "Cepmed will add a unique perspective and new types of collaboration opportunities across the network."
About DNA Direct
DNA Direct, a wholly owned subsidiary of Medco Health Solutions, Inc. (NYSE:MHS), delivers guidance and decision support for genomic medicine to patients, providers and payers. The company's comprehensive clinical programs are unique to genomic medicine and combine proprietary technology with genetic expertise; including a national call center of genetic experts, web-based applications, and educational resources and training. DNA Direct is based in San Francisco. For more information, visit www.dnadirect.com.

About Cepmed

Cepmed is a non-profit organization dedicated to promoting personalized medicine through research, commercialization, and education. Cepmed participates in several public-private partnerships that have funded studies in translational medicine and pharmacogenomics. Cepmed has established expert physician panels in cardiology, oncology, and a multi-disciplinary Strategic Advisory Panel. Cepmed is working with these panels to ensure that personalised medicine is effectively incorporated into routine medical practice, resulting in improved health care in Canada.

Founded by Dr. Jean Claude Tardif at the Montreal Heart Institute, Cepmed makes use of the Beaulieu-Saucier Pharmacogenomics Centre, the Montreal Heart Institute Coordinating Centre (MHICC) and the Montreal Heart Institute Biobank in its projects. It is a Centre of Excellence for Commercialization and Research (CECR) and supported by the Canadian Government and Genome Quebec as well as private partners including Merck, Pfizer, AstraZeneca and Novartis.

(i) "The Case for Personalized Medicine, 3rd Edition", published by the Personalized Medicine Coalition in 2011

Katherine Bonter
Director of Advocacy and Promotion
Centre of Excellence in Personalised Medicine
(514) 670-7658
kbonter@cepmed.com

Tuesday, August 16, 2011

Cancer’s Secrets Come Into Sharper Focus - Readers' Comments - NYTimes.com



free full access (pdf file) Cell - Hallmarks of Cancer: The Next Generation (published Mar 2011)



Hallmarks of Cancer: The Next Generation

Cell, Volume 144, Issue 5, 646-674, 4 March 2011
Copyright © 2011 Elsevier Inc. All rights reserved.
10.1016/j.cell.2011.02.013

Authors

Summary

The hallmarks of cancer comprise six biological capabilities acquired during the multistep development of human tumors. The hallmarks constitute an organizing principle for rationalizing the complexities of neoplastic disease. They include sustaining proliferative signaling, evading growth suppressors, resisting cell death, enabling replicative immortality, inducing angiogenesis, and activating invasion and metastasis. Underlying these hallmarks are genome instability, which generates the genetic diversity that expedites their acquisition, and inflammation, which fosters multiple hallmark functions. Conceptual progress in the last decade has added two emerging hallmarks of potential generality to this list—reprogramming of energy metabolism and evading immune destruction. In addition to cancer cells, tumors exhibit another dimension of complexity: they contain a repertoire of recruited, ostensibly normal cells that contribute to the acquisition of hallmark traits by creating the “tumor microenvironment.” Recognition of the widespread applicability of these concepts will increasingly affect the development of new means to treat human cancer

full free text: (pdf file) Cell - A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?



A ceRNA Hypothesis: The Rosetta Stone of a Hidden RNA Language?

Main Text
The Noncoding Revolution
The ceRNA Protagonists
MicroRNAs
The Transcriptome
The ceRNA Hypothesis
RNA Transcripts Communicate through the ceRNA Language
Logic and Regulation of the ceRNA Network
Experimental Evidence Supporting the ceRNA Hypothesis
ceRNAs in the Etiology of Cancer
Conclusions
Acknowledgments

Beyond the Genome, Cancer’s Secrets Come Into Sharper Focus - NYTimes.com



Understanding how cancer begins and then grows is fundamental to one day preventing the disease. Here, we explain three new theories for how cancer may form.....