Wiki: Sessile serrated adenoma
In gastroenterology, a sessile serrated adenoma (abbreviated SSA), also known as sessile serrated polyp (abbreviated SSP), is a premalignant flat (or sessile) lesions of the colon, predominantly seen in the cecum and ascending colon.
Editorial: Serrated Polyposis: The Last (or Only the Latest|[quest]|) Frontier of Familial Polyposis|[quest]| : The American Journal of Gastroenterology
The American Journal of Gastroenterology 107, 779-781 (May 2012) | doi:10.1038/ajg.2012.62
Editorial: Serrated Polyposis: The Last (or Only the Latest?) Frontier of Familial Polyposis?
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Abstract
Serrated polyps are thought to be precursors of ~15%
of colorectal cancers and clinical criteria for a serrated polyposis
(SP) syndrome have been proposed. In this issue of American Journal of
Gastroenterology, Win et al. report that family members of individuals
who meet the clinical criteria for SP are at increased risk for
colorectal and possibly pancreatic cancer. The important data presented
by Win et al. strongly support the concept that familial SP exists and
help define the patterns of risk in this syndrome. The paper also
illustrates the difficulties of trying to define a genetic syndrome on
the basis of largely retrospective clinical data and highlights the
importance of efforts to define the genetic basis of familial SP and to
study these families in a systematic, prospective manner.
