Limited prognostic value of tissue protein expression levels of cyclin E in Danish ovarian cancer patients: from the Danish ‘MALOVA’ ovarian cancer study
The
primary objective of this study was to assess the expression of cyclin E
in tumour tissues from 661 patients with epithelial ovarian tumours.
The second was to evaluate whether cyclin E tissue expression levels
correlate with clinico-pathological parameters and prognosis of the
disease. Using tissue arrays (TA), we analysed the cyclin E expression
levels in tissues from 168 women with borderline ovarian tumours (BOT)
(147 stage I, 4 stage II, 17 stage III) and 493 Ovarian cancer (OC)
patients (127 stage I, 45 stage II, 276 stage III, 45 stage IV). Using a
10% cut-off level for cyclin E overexpression, 20% of the BOTs were
positive with a higher proportion of serous than mucinous tumours.
Sixty-two per cent of the OCs were positive for cyclin E expression with
the highest percentage found in clear cell carcinomas.
Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.
Results based on univariate and multivariate survival analyses with a 10% cut-off value showed that cyclin E had no independent prognostic value. In conclusion, we found cyclin E expression in tumour tissue to be of limited prognostic value to Danish OC patients.
