abstract: Cancer and environment: Definitions and misconceptions - Environmental Research

Conclusions

Our findings emphasize the discrepancies in reporting environmental causation of cancer and the limits of inference in interpreting environmentally attributable risk estimates. Rather than achieving consensus on a single definition for the environment, we suggest the focus be on achieving transparency for any environmentally attributable risks.

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Highlights

► We report definitions of the environment and attributable risk estimates over time.
► Definitions were categorized and assessed in relation to risk estimates.
► Reported environmentally attributable risk estimates ranged from 1% to 100%.
► There are limits of inference in interpreting environmentally attributable risks.
► The focus should be on transparency in the derivation of attributable risk estimates.

Primary peritoneal and ovarian cancers: an epidemiological comparative analysis.

Cancer Causes Control. 2010 Mar 23

"We performed case-control analyses using data from the North Carolina Ovarian Cancer Study to determine risk factors that distinguish primary peritoneal cancer (PPC) from epithelial ovarian cancer (EOC).
Our risk factor analyses were restricted to invasive serous cancers including 495 EOC cases, 62 PPC cases and 1,086 control women....Although many case-control associations for the invasive serous PPC cases were similar to those of the invasive serous EOC cases, some differences were observed including a twofold increase in risk of invasive serous PPC in women who were >/=35 years at last pregnancy, whereas a decreased risk was observed for invasive serous EOC risk.
We could not confirm a previous report of an association between tubal ligation and PPC, a factor consistently associated with a decreased risk of EOC. The difference in the risk factor associations between invasive serous PPC and EOC cancers suggests divergent molecular development of peritoneal and ovarian cancers.
A larger study to determine risk factors for invasive serous PPC is warranted."

Genomics - HuGENet

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Population Research
Human Genome Epidemiology Network (HuGENet™)

HuGENetIn 1998, the National Office of Public Health Genomics established the Human Genome Epidemiology Network (HuGENet™) to help translate genetic research findings into opportunities for preventive medicine and public health by advancing the synthesis, interpretation, and dissemination of population-based data on human genetic variation in health and disease.

HuGENet™ is interested in establishing collaborations with individuals and organizations working on population-based research involving genetic information. Learn how to participate in HuGENet™.

Epidemiology of Ovarian Cancer in African American Women | Institute for Health Research and Policy | University of Illinois, Chicago

Principal investigator
Therese A. Dolecek, PhD
Co-investigator(s)
Faith G. Davis, PhD
Bridget McCarthy, PhD

Funding Agency
National Cancer Institute through Duke University

Start date
04/01/2010
End date
03/31/2015
Total award
$1,150,609

About this grant
This grant is a subcontract of a larger grant at Duke University.
Parent Study
Epidemiology of Ovarian Cancer in African American Women
PI of Parent Study
Joellen Schildkraut, PhD, MPH
Duke University