open access: PLoS ONE: Hormone Treatment, Estrogen Receptor Polymorphisms and Mortality: A Prospective Cohort Study (in women 65yrs+)

PLoS ONE: Hormone Treatment, Estrogen Receptor Polymorphisms and Mortality: A Prospective Cohort Study

Conclusions/Significance

The risk of mortality was not associated with HT duration, type or age at initiation. It was however not equal across all women, with some women appearing genetically more vulnerable to the effects of HT in terms of their estrogen receptor genotype. These findings, if confirmed in another independent study, may help explain the differential susceptibility of women to the beneficial or adverse effects of HT.