WIKI: Lipid metabolism refers to the processes that involve the intercourse and degradation of lipids.
The types of lipids involved include:
- Bile salts
- Cholesterols
- Eicosanoids
- Glycolipids
- Ketone bodies
- Fatty acids - see also fatty acid metabolism
- Phospholipids
- Sphingolipids
- Steroid - see also steroidogenesis
- Triacylglycerols (fats) - see also lipolysis and lipogenesis
Lipid Profiles and Risk of Breast and Ovarian Cancer in the Swedish AMORIS Study
Background:
Obesity is a risk factor for
breast (BCa) and ovarian cancer (OCa); the mechanisms of action are not
completely
understood. Perturbed lipid metabolism often
accompanies obesity; we therefore ascertained the associations between
lipid
components and BCa and OCa risk in a
prospective cohort study.
Methods:
234,494 women with baseline measurements
of triglycerides (TG) and total cholesterol(TC) and glucose were
selected
from the AMORIS database. 27,394 had measurements
of HDL,LDL, apolipoprotein (Apo) B and A-I. Associations between quartiles
and dichotomized values of lipid components and BCa
and OCa risk were analysed using Cox proportional hazard models.
Results:
We identified 6,105 women diagnosed with
BCa and 808 women diagnosed with OCa. A weak trend was observed between
TG and BCa (HR: 1.01 (CI95% 0.94-1.09), 0.93
(0.86-1.00) 0.91
(0.84-0.99) 2nd 3rd and 4th quartiles; P = 0.01).
No other associations between lipid components and risk of BCa or OCa
showed
statistical significance.
Conclusions:
A weak protective association was
found between levels of TG and risk of BCa.
Impact: An analysis including information on tumour
characteristics of OCa and BCa may provide more insight in possible
links
between lipid metabolism and the risk of these
cancers.
