Access : Mutation analysis of RAD51D in non-BRCA1|[sol]|2 ovarian and breast cancer families : British Journal of Cancer
Mutation analysis of RAD51D in non-BRCA1/2 ovarian and breast cancer families
Abstract
Background:
Recent
data show that mutations in RAD51D have an aetiological role in ovarian
carcinoma, yet mutations do not appear to be associated with an
increased risk for breast cancer. We studied ovarian and breast cancer
families having at least one woman affected by ovarian carcinoma, to
assess the importance of RAD51D mutations in such families.
Methods:
The coding region of the RAD51D gene was analysed in 175 BRCA1/2-negative
families with family histories of both ovarian and breast cancer
ascertained from two Canadian and two Belgian institutions.
Conclusion:
RAD51D should be included in genetic screening of ovarian cancer families that do not have BRCA1/BRCA2
mutations. We show that mutations are more likely to be found in
families with two or more ovarian cancers, or in probands with
first-degree relatives with ovarian cancer, and we feel testing should
be preferentially offered to affected women from such families.
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