OVARIAN CANCER and US: genetic variations

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Showing posts with label genetic variations. Show all posts
Showing posts with label genetic variations. Show all posts

Wednesday, September 08, 2010

Germline Genetic Variation, Cancer Outcome, and Pharmacogenetics — JCO



Abstract

"Studies of the role of germline or inherited genetic variation on cancer outcome can fall into three distinct categories. First, the impact of highly penetrant but lowly prevalent mutations of germline DNA on cancer prognosis has been studied extensively for BRCA1 and BRCA2 mutations as well as mutations related to hereditary nonpolyposis colorectal cancer syndrome (Lynch Syndrome). ...."cont'd