ScienceDirect.com - Gynecologic Oncology - Green Tea for Ovarian Cancer Prevention and Treatment: A Systematic Review of the in Vitro, in Vivo and Epidemiological Studies
Abstract
Objective
This
systematic review was conducted to examine the effects of green tea or
green tea components on the prevention and progression of epithelial
ovarian cancer.
Methods
Using Medline, EMBASE and SciVerse (last researched: July 2011), we retrieved 22 articles including 5 epidemiological studies.
Results
In
epithelial ovarian cancer cell lines, green tea and green tea
components have been shown to down regulate the expression of proteins
involved in inflammation, cell signalization, cell motility and
angiogenesis. Green tea and green tea components would induce apoptosis
and could potentiate the effects of cisplatin, a chemotherapeutic agent.
In human observational studies, significant associations between green
tea intake and both decreased ovarian cancer occurrence and better
prognosis were reported.
Conclusions
Available
literature suggests potential molecular targets for green tea in
ovarian cancer treatment and also provides data supporting the clinical
evaluation of the role of green tea or green tea components in ovarian
cancer prevention and treatment.
Highlights
►
Green tea decreases ovarian cancer-associated protein expression in
cell lines.
► Green tea-fed mice develop smaller, less vascularized ovarian cancer xenografts.
► Green tea intake could decrease ovarian cancer occurrence and recurrence in women.
► Green tea-fed mice develop smaller, less vascularized ovarian cancer xenografts.
► Green tea intake could decrease ovarian cancer occurrence and recurrence in women.
