Comparison of gene expression patterns between avian and human ovarian cancers

Conclusions

Gene expression of spontaneous ovarian cancer in the chicken is comparable
to gene expression patterns of human ovarian cancer.

Research Highlights

► Avian tubal cancer and ovarian cancer gene expression patterns
are different.
► Chicken ovarian cancer expression predicts expression patterns
in human ovarian cancer.

Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year

ConclusionsThese findings show that 10% flaxseed supplementation for 1 year in the laying hen results in a significant reduction in the severity of ovarian cancer, but no change in the incidence of the disease. Hens fed flaxseed had overall better health and reduced mortality. These findings may provide the basis for a clinical trial that evaluates the efficacy of flaxseed as a chemosuppressant of ovarian cancer in women.

abstract: Decreased severity of ovarian cancer and increased survival in hens fed a flaxseed-enriched diet for 1 year

OBJECTIVE: "With the exception of the laying hen, no other animal model of spontaneous ovarian surface epithelial cancer replicates the human disease."