Metastases from other solid organ primaries
"Breast cancer is the most common type of primary malignancy
in women, but metastatic spread to the breast from other solid
organs, although rare, has been reported 51–53 and may be the
first sign of malignancy.54..."
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Abstract: Although much emphasis has been placed on the primary presentations of breast cancer, little focus has been placed on how systemic illnesses may affect the breast. In this article, we discuss systemic illnesses that can manifest in the breast. We summarize the clinical features, imaging, histopathology, and treatment recommendations for endocrine, vascular, systemic inflammatory, infectious, and hematologic diseases, as well as for the extramammary malignancies that can present in the breast. Despite the rarity of these manifestations of systemic disease, knowledge of these conditions is critical to the appropriate evaluation and treatment of patients presenting with breast symptoms.
References as noted above (Metastases from other solid organ primaries):
51. Akcay MN. Metastatic disease in the breast. Breast. 2002;11(6):
526–528.
52. Lee SK, Kim WW, Kim SH, et al. Characteristics of metastasis in thebreast from extramammary malignancies. J Surg Oncol. 2010;101(2):137–140.
Blogger's Note: - excerpt from reference #52 above:
"The breast is an uncommon site for metastasis from
extramammary tumors with incidence of 0.4 - 1.3%.1,2 In
about 25–40% of cases, metastasis to the breast is the
initial manifestation of the disease.2 The common
sources of primary tumors are haematological
malignancies, malignant melanoma, lung tumors, renal
cell carcinoma, ovarian tumors, thyroid carcinomas and
small bowel carcinoid.4,6 Other tumors metastasized to
breast are prostate, stomach, malignant mesothelioma
and rhabdomyosarcoma.9"
53. Young JL Jr, Ward KC, Wingo PA, Howe HL. The incidence of
malignant non-carcinomas of the female breast. Cancer Causes Control.
2004;15(3):313–319.
54. Hamby LS, McGrath PC, Cibull ML, Schwartz RW. Gastric carcinoma
metastatic to the breast. J Surg Oncol. 1991;48(2):117–121.
