Showing posts with label interleukin research. Show all posts
Showing posts with label interleukin research. Show all posts
Monday, May 28, 2012
IL-13 regulates cancer invasion and metastasis through IL-13Rα2 via ERK/AP-1 pathway in mouse model of human ovarian cancer.
IL-13 regulates cancer invasion and metastasis through IL-13Rα2 via ERK/AP-1 pathway in mouse model of human ovarian cancer
"Taken together, IL-13Rα2 is involved in cancer metastasis through activation of ERK/AP-1 and that targeting IL-13Rα2 might not only directly kill primary tumors but also prevent cancer metastasis."
Tuesday, February 07, 2012
Researchers Find Ovarian Cancer Risk Related To Inherited Inflammation Genes - newswise
"... The authors noted that in 2011 there were an estimated 225,500 new cases of ovarian cancer worldwide. Although some women are at greatly elevated risks of ovarian cancer due to inherited mutations in the BRCA1 and BRCA2 genes (and Lynch Syndrome amongst other rarer syndomes), these are rare in the population and account for perhaps 10 percent of cases. However, a substantial portion of genetic influence on ovarian cancer risk has been “unexplained” and some of that may be due to common genetic variants. Sellers points out that “the Il1A variant that was most strongly protective is carried by 30 percent of women in the study, so the impact at the population level is not trivial.”
Blogger's Note: interleukins and therefore the interest in interleukin research noting the variables within (eg. IL2;IL3..) as an example:
(2009) Interleukin 2-mediated conversion of ovarian cancer-associated CD4+ regulatory T cells into proinflammatory interleukin 17-producing helper T cells.
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