abstract: Unopposed estrogen and estrogen plus progestin menopausal hormone therapy and lung cancer risk in the NIH-AARP Diet and Health Study Cohort

Abstract

PURPOSE:

Previous studies have reported that lung cancer risk may be decreased, increased, or unaffected by prior use of menopausal hormone therapy (MHT).

CONCLUSIONS:

Our results failed to support any substantial alterations in lung cancer risk associated with use of either unopposed estrogen or estrogen plus progestin MHT, even when detailed exposure measures and other risk predictors were considered.

Removing ovaries may boost lung cancer risk: Study media article

"We found that women who experienced non-natural menopause are at almost twice the risk of developing lung cancer compared to women who experienced natural menopause," Anita Koushik, a researcher at the Universite de Montreal's Department of Social and Preventive Medicine, said in announcing her team's findings Tuesday.

"This increased risk of lung cancer was particularly observed among women who had non-natural menopause by having had both their ovaries surgically removed."

It's the second study this year to associate bilateral oophorectomy — removal of both ovaries — with higher odds of developing lung cancer...."