Single antibody (CD47 ) shrinks variety of human tumors transplanted into mice, Stanford study shows | e! Science News

Single antibody shrinks variety of human tumors transplanted into mice, Stanford study shows | e! Science News

Human tumors transplanted into laboratory mice disappeared or shrank when scientists treated the animals with a single antibody, according to a new study from the Stanford University School of Medicine. The antibody works by masking a protein flag on cancer cells that protects them from macrophages and other cells in the immune system. The scientists achieved the findings with human breast, ovarian, colon, bladder, brain, liver and prostate cancer samples. It is the first antibody treatment shown to be broadly effective against a variety of human solid tumors, and the dramatic response -- including some overt cures in the laboratory animals -- has the investigators eager to begin phase-1 and -2 human clinical trials within the next two years.........

Cancer drugs affect mouse genomes for generations (mice offspring) : Nature News & Comment

"....Furthermore, children who are treated for cancer will not have children of their own for years or decades afterwards. Mice only live about two years, and the ones in Dubrova’s study reproduced a few months after their exposure to the drugs. “I would be very careful in interpreting this data,” Dubrova says."

".....But he (Joe O’Sullivan) also cautions against reading too much into the implications for humans who receive chemotherapy treatments, noting that that the few who do go on to have children are generally asked to wait at least a year after treatment before doing so. “It’s something we’ve generally advised for a long time,” he says, “even though we haven’t had much evidence to back it up.”"

Progesterone induces adult mammary stem cell expansion : Nature

Note: in research; defining the role of progesterones

"Reproductive history is the strongest risk factor for breast cancer after age, genetics and breast density. Increased breast cancer risk is entwined with a greater number of ovarian hormone-dependent reproductive cycles, yet the basis for this predisposition is unknown..........The emerging role of MaSCs (mammary stem cells) in cancer initiation warrants the study of ovarian hormones in MaSC homeostasis. Here we show that the MaSC pool increases 14-fold during maximal progesterone levels at the luteal dioestrus phase of the mouse."

NCI Scientists Restore DNA Repair in Mice with BRCA1 Gene Mutations

Mice get new role in search for cancer drugs - The Boston Globe

Note: includes public comments