Osteopontin is a new target molecule for ovarian clear cell carcinoma therapy

Abstract (in research)

"Recent studies have demonstrated overexpression of osteopontin (OPN) in ovarian clear cell carcinoma.
Here, we revealed the role of OPN in invasiveness in ovarian clear cell carcinoma......Immunofluorescence analysis revealed statistically significant differences among the histological groups, and ovarian clear cell carcinoma expressed a strong OPN signal....Simvastatin significantly reduced expression of OPN and the integrins, and decreased ECM invasion. RNA interference also suppressed ECM invasion....We thus conclude that OPN regulation could have a crucial role in ovarian clear cell carcinoma therapy."