Showing posts with label osteoporosis. Show all posts
Showing posts with label osteoporosis. Show all posts
Friday, July 01, 2011
Sunday, April 24, 2011
free full access: Calcium supplements with/without vitamin D and risk of cardiovascular events: reanalysis of the Women’s Health Initiative - bmj.com (including responses)
Abstract/Conclusions:
Calcium supplements with or without vitamin D modestly increase the risk of cardiovascular events, especially myocardial infarction, a finding obscured in the WHI CaD Study by the widespread use of personal calcium supplements. A reassessment of the role of calcium supplements in osteoporosis management is warranted.
excerpt (from full text):
"...An important question that arises is whether co-administered
calcium and vitamin D affects cardiovascular risk. The Women’s Health
Initiative reported no adverse effect of calcium and vitamin D (1 g
calcium/400 IU vitamin D daily) on any cardiovascular end point in their
large (n=36 282), seven year, randomised, placebo controlled trial.3 4
However, 54% of the participants were taking personal (non-protocol)
calcium supplements at randomisation and 47% were taking
personal vitamin D supplements,
effectively rendering this trial a comparison of higher dose and lower
dose calcium and vitamin
D for most of the participants.
Allowing clinical trial
participants free access to the intervention being studied is unusual
and has the potential to obscure both adverse and beneficial effects..."
add your opinions
calcium
,
osteoporosis
,
post WHI
,
supplements
,
vitamin D
Monday, June 07, 2010
Friday, March 05, 2010
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