OVARIAN CANCER and US: ovarian cancer target therapies

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Showing posts with label ovarian cancer target therapies. Show all posts
Showing posts with label ovarian cancer target therapies. Show all posts

Saturday, January 21, 2012

open access: Review - 2010 Targeted Therapies in Epithelial Ovarian Cancer




Review

Targeted Therapies in Epithelial Ovarian Cancer

Abstract:

Molecularly targeted therapy is relatively new to ovarian cancer despite the unquestionable success with these agents in other solid tumours such as breast and colorectal cancer. Advanced ovarian cancer is chemosensitive and patients can survive several years on treatment. However chemotherapy diminishes in efficacy over time whilst toxicities persist. Newer biological agents that target explicit molecular pathways and lack specific chemotherapy toxicities such as myelosuppression offer the advantage of long-term therapy with a manageable toxicity profile enabling patients to enjoy a good quality of life.

In this review we appraise the emerging data on novel targeted therapies in ovarian cancer. We discuss the role of these compounds in the front-line treatment of ovarian cancer and in relapsed disease; and describe how the development of predictive clinical, molecular and imaging biomarkers will define the role of biological agents in the treatment of ovarian cancer.