OVARIAN CANCER and US: p53; Ovarian cancer; Biomarker; Autoantibody; p53; CA125

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Showing posts with label p53; Ovarian cancer; Biomarker; Autoantibody; p53; CA125. Show all posts
Showing posts with label p53; Ovarian cancer; Biomarker; Autoantibody; p53; CA125. Show all posts

Tuesday, January 03, 2012

Potentiation of a p53-SLP vaccine by cyclophosphamide in ovarian cancer, a single arm phase II study.



Abstract

The purpose of the current phase II single-arm clinical trial was to evaluate whether pre-treatment with low-dose cyclophosphamide improves immunogenicity of a p53-synthetic long peptide (SLP) vaccine in patients with recurrent ovarian cancer. Ovarian cancer patients with elevated serum levels of CA-125 after primary treatment were immunized four times with the p53-SLP vaccine.........The outcome of this phase II trial warrants new studies on the use of low-dose cyclophosphamide to potentiate the immunogenicity of the p53-SLP vaccine, or other anti-tumor vaccines.