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Showing posts with label p53. Show all posts
Showing posts with label p53. Show all posts
Saturday, May 19, 2012

paywalled: Antigen-specific immunotherapy in ovarian cancer and p53 as tumor antigen.

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Antigen-specific immunotherapy in ovarian cancer and p53 as tumor antigen. : Abstract Immunotherapy for ovarian cancer is one of the n...
Thursday, March 01, 2012

still recruiting: A (phase 11) Study of MK-1775 in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carboplatin Alone for Participants With Platinum-Sensitive Ovarian Tumors With the P53 Gene Mutation (MK-1775-004) - Full Text View - ClinicalTrials.gov

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Official Title: A Randomized, Phase II Study Evaluating MK-1775 in Combination With Paclitaxel and Carboplatin Versus Paclitaxel and Carb...
Wednesday, August 03, 2011

p53 Signature and Serous Tubal In-situ Carcinoma in Cases of Primary Tubal and Peritoneal Carcinomas and Serous Borderline Tumors of the Ovary

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Tuesday, June 07, 2011

UK media: Sufferers of ovarian cancer get new hope - p53 gene

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Sunday, February 20, 2011

Long-term clinical and immunological effects of p53-SLP® vaccine in ovarian cancer patients

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Abstract Vaccine-induced p53-specific immune responses were previously reported to be associated with improved response to secondary che...
Monday, September 20, 2010

Risk factors for non-invasive lesions of the fallopian tube in BRCA mutation carriers (study of 173 BRCA mutation carriers)

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Objective To identify risk factors for the presence of a non-invasive lesion of the fallopian tube in women with a BRCA1 or BRCA2 mutati...
Tuesday, August 10, 2010

Objective To identify risk factors for the presence of a non-invasive lesion of the fallopian tube in women with a BRCA1 or BRCA2 mutation (abstract)

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Objective To identify risk factors for the presence of a non-invasive lesion of the fallopian tube in women with a BRCA1 or BRCA2 mutat...
Tuesday, June 15, 2010

p53 autoantibodies as potential detection and prognostic biomarkers in serous ovarian cancer

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IMPACT: Although their utility as a preoperative diagnostic biomarker, beyond CA 125 and HE4, is limited, p53-AAb are prognostic for impr...
Friday, June 11, 2010

A Mechanism Behind Negative Tumor Suppressor Gene Function Identified - p53

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Note : the p53 gene has been studied extensively for decades including p53 vaccines, hopefully new research will move research on p53 quickl...
Thursday, May 27, 2010

Abstract / full free text: Expression signatures of TP53 mutations in serous ovarian cancers

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Conclusions This represents the first attempt to define a genomic signature of TP53 mutation in ovarian cancer. Patterns of gene expressio...
Wednesday, April 14, 2010

Association between DNA damage response and repair genes and risk of invasive serous ovarian cancer.

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Note : in research/technical
Friday, March 05, 2010

Molecular Profiling Uncovers a p53-Associated Role for MicroRNA-31 in Inhibiting the Proliferation of Serous Ovarian Carcinomas and Other Cancers

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Note : miR-31 (rna/genome/gene) "Our findings reveal that loss of miR-31 is associated with defects in the p53 pathway and functions...

p53 Autoantibodies as Potential Detection and Prognostic Biomarkers in Serous Ovarian Cancer

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CONCLUSIONS : Antibodies to p53 are detected in the sera of 42% of patients with advanced serous ovarian cancer. Impact: Although their ...
Wednesday, January 06, 2010

full free access: TP53 Mutations in Human Cancers: Origins, Consequences, and Clinical Use — Cold Spring Harbor Perspectives in Biology

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Somatic TP53 mutations occur in almost every type of cancer at rates from 38%–50% in ovarian and..... .....TP53 mutations, but not p53 posit...