"....Detection before the malignancy spreads or at the early stage would greatly improve the survival and benefit patient health. In this report, we present an integrated optical coherence tomography (OCT), ultrasound (US) and photoacoustic imaging (PAI) prototype endoscopy system for ovarian tissue characterization."
"Combining OCT, US and PAI would further provide complementary tissue optical absorption, scattering information, and deep tissue structures. Previously, Yang et al. developed a photoacoustic endoscopy [24]; Yin et al. reported an integrated intravascular OCT and ultrasound imaging probe [25,26]; Wang et al. demonstrated an ultrasound guided spectroscopic intravascular photoacoustic imaging system [27]; Li et al. [28] and Jiao et al. [29] both introduced the integrated OCT and photoacoustic microscopy. For the above referenced studies, either one or two imaging modalities were investigated, although some were not suitable for endoscopy applications. This study, to the best of our knowledge, reports the first prototype system that integrates OCT, US and PAI modalities for endoscopy applications. The performance of the system in ovarian tissue characterization has been demonstrated using ex vivo porcine and human ovaries."
"
Summary
"We have
developed the first integrated OCT, US and PAI endoscopy imaging system
prototype and explored its application in ovarian tissue
characterization. The absorption information provided by PAI, the
high-resolution subsurface morphological image provided by OCT and the
deeper tissue structures imaged by US demonstrate the great synergy of
the combined endoscopy over each modality alone. The initial results
have shown that the hybrid device has a potential in ovarian cancer
detection and characterization."
