Showing posts with label postmenopausal hormone therapy. Show all posts
Showing posts with label postmenopausal hormone therapy. Show all posts
Wednesday, May 02, 2012
paywalled Primary fallopian tube carcinoma risk in users of postmenopausal hormone therapy in Finland
Primary fallopian tube carcinoma risk in users of postmenopausal hormone therapy in Finland: Publication year: 2012
Source:Gynecologic Oncology
Objective Primary fallopian tube carcinoma (PFTC) is a rare malignancy and only sparse data exist on its possible association with postmenopausal hormone therapy (HT). We therefore studied this association in a nationwide cohort of Finnish HT users.
Conclusions The long-term, sequential use of EPT associates with an increased risk for PFTC. In absolute terms, 4 additional cases of PFTC would be detected in 10-year follow-up of 10,000 women who have used EPT for at least 5 years
add your opinions
estrogen therapy
,
fallopian tube cancer
,
postmenopausal hormone therapy
Saturday, April 21, 2012
abstract: Hormone Therapy and Different Ovarian Cancers: A National Cohort Study (postmenopausal women/does not include reference to clear cell ovarian)
Blogger's Note: the abstract makes no reference to clear cell ovarian, given the number of women followed this omission (in the abstract) is curious
Hormone Therapy and Different Ovarian Cancers: A National Cohort Study
Abstract
Postmenopausal hormone therapy use
increases the risk of ovarian cancer. In the present study, the authors
examined the risks
of different histologic types of ovarian cancer
associated with hormone therapy.
Using Danish national registers, the
authors
identified 909,946 women who were followed from
1995–2005. The women were 50–79 years of age and had no prior
hormone-sensitive
cancers or bilateral oophorectomy.
Hormone therapy
prescription data were obtained from the National Register of Medicinal
Product Statistics. The National Cancer and
Pathology Register provided data on ovarian cancers, including
information about
tumor histology......... In an average of 8.0 years of follow
up, 2,681 cases of epithelial ovarian cancer were detected.
Compared
with
never users, women taking unopposed oral estrogen
therapy had increased risks of both serous tumors and
endometrioid tumors but
decreased risk of mucinous tumors. Similar increased risks of serous and
endometrioid
tumors were found with estrogen/progestin therapy,
whereas no association was found with mucinous tumors.
Consistent with
results from recent cohort studies, the authors
found that ovarian cancer risk varied according to tumor histology. The
types
of ovarian tumors should be given attention in
future studies.
add your opinions
endometrioid
,
ERT
,
hormone therapy
,
HRT
,
mucinous
,
postmenopausal hormone therapy
,
serous
Wednesday, August 18, 2010
Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement - multinational/abstract/eletters/response
This version published online on June 21, 2010
Journal of Clinical Endocrinology & Metabolism , doi:10.1210/jc.2009-2509
Accepted on April 21, 2010
Postmenopausal Hormone Therapy: An Endocrine Society Scientific Statement
Richard J. Santen*,Division of Endocrinology and Metabolism (R.J.S.), Department of Obstetrics and Gynecology (J.V.P.), University of Virginia, Charlottesville, Virginia 22908; Tufts University School of Medicine (R.H.K.), Molecular Cardiology Research Institute, Tufts Medical Center, Boston, Massachusetts 02111; Jean Hailes Research Centre (H.T.), School of Public Health, Melbourne, Australia 3168; Prince Henry's Institute of Medical Research (H.G.B.), Monash Medical Centre, Melbourne, Australia 3168; Department of Medicine/Women's Health Program (S.R.D.), Monash University, Melbourne, Australia 3181; Departments of Health Research and Policy (Epidemiology) and of Neurology and Neurological Sciences (V.W.H.), Stanford University, Stanford, California 94305; Departments of Pathology and Immunology (D.C.A.) and Surgery (G.A.C.), Washington University School of Medicine, St. Louis, Missouri 63110; Department of Nutrition Sciences (B.A.G.), University of Alabama at Birmingham, Birmingham, Alabama 35294; St. Joseph Hospital (M.K.), Internal Medicine, Reichert Health Center, Ypsilanti, Michigan 48197; Division of Immunology and Rheumatology, Ohio State University School of Medicine (W.N.J., S.P.A.), Columbus, Ohio 43219; University of Pisa (M.G.), Department of Obstetrics and Gynecology, Pisa I-56100, Italy; University of Toronto (N.B., L.M.), Department of Nutritional Sciences, Department of Medicine, Toronto, Ontario, Canada M5G 2C1; Cedars-Sinai Medical Center (G.D.B.), Department of Medicine, Los Angeles, California 90048; Columbia University Medical Center (R.A.L.), Department of Obstetrics and Gynecology, New York, New York 10037; Eastern Virginia Medical School (D.F.A.), Clinical Research Center, Norfolk, Virginia 23507; North American Menopause Society (W.H.U.), Mayfield Heights, Ohio 44124; Massachusetts General Hospital (K.A.M.), UptoDate, Waltham, Massachusetts 02453; University of North Carolina at Chapel Hill (D.R.R.), Chapel Hill, North Carolina 27516; Section of Dermatology (D.M.T.), Hershey Medical Center, Pennsylvania State University School of Medicine, Hershey, Pennsylvania 17033; King's Breast Care (J.M.), King's College Hospital, London SE5 9RS, United Kingdom; and Harvard Medical School (J.E.M.), Brigham and Women's Hospital, Boston, Massachusetts 02215
Objective: Our objective was to provide a scholarly review of the published literature on menopausal hormonal therapy (MHT), make scientifically valid assessments of the available data, and grade the level of evidence available for each clinically important endpoint.
Participants in Development of Scientific Statement: The 12-member Scientific Statement Task Force of The Endocrine Society selected the leader of the statement development group (R.J.S.) and suggested experts with expertise in specific areas. In conjunction with the Task Force, lead authors (n = 25) and peer reviewers (n = 14) for each specific topic were selected. All discussions regarding content and grading of evidence occurred via teleconference or electronic and written correspondence. No funding was provided to any expert or peer reviewer, and all participants volunteered their time to prepare this Scientific Statement.
Evidence: Each expert conducted extensive literature searches of case control, cohort, and randomized controlled trials as well as meta-analyses, Cochrane reviews, and Position Statements from other professional societies in order to compile and evaluate available evidence. No unpublished data were used to draw conclusions from the evidence.
Consensus Process: A consensus was reached after several iterations. Each topic was considered separately, and a consensus was achieved as to content to be included and conclusions reached between the primary author and the peer reviewer specific to that topic. In a separate iteration, the quality of evidence was judged using the GRADE (Grading of Recommendations, Assessment, Development, and Evaluation) system in common use by The Endocrine Society for preparing clinical guidelines. The final iteration involved responses to four levels of additional review: 1) general comments offered by each of the 25 authors; 2) comments of the individual Task Force members; 3) critiques by the reviewers of the Journal of Clinical Endocrinology & Metabolism; and 4) suggestions offered by the Council and members of The Endocrine Society. The lead author compiled each individual topic into a coherent document and finalized the content for the final Statement. The writing process was analogous to preparation of a multiauthored textbook with input from individual authors and the textbook editors.
Conclusions: The major conclusions related to the overall benefits and risks of MHT expressed as the number of women per 1000 taking MHT for 5 yr who would experience benefit or harm. Primary areas of benefit included relief of hot flashes and symptoms of urogenital atrophy and prevention of fractures and diabetes. Risks included venothrombotic episodes, stroke, and cholecystitis. In the subgroup of women starting MHT between ages 50 and 59 or less than 10 yr after onset of menopause, congruent trends suggested additional benefit including reduction of overall mortality and coronary artery disease. In this subgroup, estrogen plus some progestogens increased the risk of breast cancer, whereas estrogen alone did not. Beneficial effects on colorectal and endometrial cancer and harmful effects on ovarian cancer occurred but affected only a small number of women. Data from the various Women's Health Initiative studies, which involved women of average age 63, cannot be appropriately applied to calculate risks and benefits of MHT in women starting shortly after menopause. At the present time, assessments of benefit and risk in these younger women are based on lower levels of evidence.
eLetters:
Read all eLetters
- Statistical Analysis in the Postmenopausal Hormone Therapy
- Joseph W. Goldzieher
- JCEM Online, 17 Aug 2010 [Full text]
"It is to be hoped that this monumental, desperately needed report will help to counter the persistent damaging effect of the 2002 WHI publication, and have an influence that ranges from generators of policy and guidelines to the most remote doctor/patient interaction...."
add your opinions
endocrine policy statement
,
multinational study
,
postmenopausal hormone therapy
,
WHI
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