Showing posts with label stage 1V. Show all posts
Showing posts with label stage 1V. Show all posts
Thursday, May 24, 2012
Wednesday, February 29, 2012
Neoadjuvant chemotherapy, interval debulking surgery or primary surgery in ovarian carcinoma FIGO stage IV? 10.1016/j.ejca.2012.01.031 : European Journal of Cancer
Abstract
Objectives
The aim of this study was to investigate the impact of surgical approach, the extent of surgery and chemotherapy on overall survival in patients with ovarian carcinoma (OC) stage IV.
Methods
We retrospectively collected population-based data from the Norwegian Radium Hospital code registry on the diagnosis and surgery of 238 patients diagnosed with OC stage IV from 1996–2005. All patients received platinum-based chemotherapy. Surgical approach was registered as primary debulking surgery (PDS), interval debulking surgery (IDS) and delayed primary surgery (DPS). Surgery level was classified as radical surgery (RS), standard surgery (SS) or suboptimal surgery (SUBS). Univariate and multivariate analyses identified prognostic factors in PDS, IDS and DPS groups and subgroups.
Results
There were no differences in overall survival between the PDS, IDS and DPS groups. Surgery level was significantly associated with overall survival in the whole cohort (p < 0.001), the PDS and IDS groups, but not in the DPS group. More patients with RS achieved no residual tumour (RT), but overall survival was not superior compared to no RT in the SS group. In 66 patients with no RT there were no differences in overall survival between those who underwent PDS, IDS and DPS. Chemotherapy with platinum/paclitaxel tended to improve survival. RT, World Health Organisation (WHO) performance status and histology were prognostic factors for overall survival in the whole cohort.
Conclusion
No RT remains the objective, whether PDS, IDS or DPS is performed, and no differences in overall survival were found in the three treatment groups.
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stage 1V
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stage 1V ovarian cancer survival
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surgery
Saturday, July 30, 2011
ELC : Interactive Case: Ovarian Cancer: Symptomatic Stage IV Disease Dr Thomas Herzo
Note: requires registration (free)
Interactive Case: Ovarian Cancer: Symptomatic Stage IV Disease Dr Thomas Herzog presents a provocative discussion focusing on options for treatment of a patient presenting with stage IV disease. His discussion incorporates the contemporary option of neo-adjuvant chemotherapy as well as the addition of an anti-angiogenic agent into the initial treatment regimen.
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