OVARIAN CANCER and US: synergy

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Showing posts with label synergy. Show all posts
Showing posts with label synergy. Show all posts

Thursday, February 09, 2012

abstract: How valid are claims for synergy in published clinical studies?



Abstract

Background: Clinical trials evaluating drug combinations are often stimulated by claims of synergistic interactions in preclinical models. Overuse or misuse of the term synergy could lead to poorly designed clinical studies.

Conclusions: Synergy is cited frequently in phase I and phase II studies to justify the evaluation of a specific drug combination. Inappropriate methods for evaluation of synergy and poor assessment of therapeutic index have been used in most preclinical articles.