Variants of Uncertain Significance in Breast Cancer–Related Genes: Real-World Implications for a Clinical Conundrum. Part One: Clinical Genetics Recommendations
Article Outline
- Positive BRCA1 or BRCA2
- Negative BRCA1 and BRCA2
- Variant of Uncertain Clinical Significance
- Case No. 1: BRCA1 VUS
- Case No. 2: BRCA2 VUS
- Case No. 3: BRCA2 VUS Favoring Polymorphism
- Clinical Discussion Points (Cases No. 2 and 3)
- Clinical Geneticists' Opinions
- Cancer Geneticists' Opinions
- Clinical Geneticists' Opinions
- Discussion
- References
- Copyright