OVARIAN CANCER and US: whole genome testing

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Showing posts with label whole genome testing. Show all posts
Showing posts with label whole genome testing. Show all posts

Wednesday, May 09, 2012

paywalled: The Predictive Capacity of Personal Genome Sequencing - Science Translational Medicine



[Research Articles] The Predictive Capacity of Personal Genome Sequencing:

New DNA sequencing methods will soon make it possible to identify all germline variants in any individual at a reasonable cost. However, the ability of whole-genome sequencing to predict predisposition to common diseases in the general population is unknown. To estimate this predictive capacity, we use the concept of a "genometype." A specific genometype represents the genomes in the population conferring a specific level of genetic risk for a specified disease. Using this concept, we estimated the maximum capacity of whole-genome sequencing to identify individuals at clinically significant risk for 24 different diseases.