abstract : Laparoscopic optical coherence tomography imaging of human ovarian cancer

Note: advances in the imaging of ovarian cancer

media article: Testing for Breast Cancer Gene: No Simple Answers

Surgery duration linked to infectious complications, hospital stay - Anesthesiology Videos - The Doctor's Channel

not specific to ovarian cancer

full free access: Targeting Insulin and Insulin-Like Growth Factor Pathways in Epithelial Ovarian Cancer

Note: a highly technical paper - look at Table 2; 7.5 = clinical trials link; 8.0 = Conclusion

press release: HE4 - Abbott Receives European Regulatory Approval for New Ovarian Cancer Diagnostic Test

Contemporary Management of and Future Directions in Ovarian Cancer - Cancer Network

Note: this was posted in November, but I have brought the posting date forward to coincide with other like articles, so both can be viewed at the same time. Access to this article requires that you sign on to the website (free).

full free access: Jan 2/2010 - Targeted Therapy in Ovarian Cancer

Review Article
Targeted Therapy in Ovarian Cancer
Lyndsay J. Willmott and John P. Fruehauf
Chao Family Comprehensive Cancer Center, University of California Irvine, Orange, CA 92868, USA Academic Editor: Charles F. Levenback

full free access: (2010) Germline Mutations and Polymorphisms in the Origins of Cancers in Women

Note: a good explanation in (close to) plain english on a subject that is anything but easy to understand.

Will Myriad's Marketing to Mammogram Centers Ease or Fan Over-Testing Concerns with BRACAnalysis? | Pharmacogenomics Reporter | DxPGx | GenomeWeb

Defective Mismatch Repair, Microsatellite Mutation Bias, and Variability in Clinical Cancer Phenotypes -- Shah et al. 70 (2): 431 -- Cancer Research

Abstract:
"Microsatellite instability is associated with 10% to 15% of colorectal, endometrial, OVARIAN, and gastric cancers, and has long been used as a diagnostic tool for hereditary nonpolyposis colorectal carcinoma–related cancers. Tumor-specific length alterations within microsatellites are generally accepted to be a consequence of strand slippage events during DNA replication, which are uncorrected due to a defective postreplication mismatch repair (MMR) system. Mutations arising within microsatellites associated with critical target genes are believed to play a causative role in the evolution of MMR-defective tumors. In this review, we summarize current evidence of mutational biases within microsatellites arising as a consequence of intrinsic DNA sequence effects as well as variation in MMR efficiency. Microsatellite mutational biases are generally not considered during clinical testing; however, we suggest that such biases may be clinically significant as a factor contributing to phenotypic variation among microsatellite instability–positive tumors."

ACS :: Possible Risks of Blood Product Transfusions

Comment: Before Erythropoiesis-stimulating agents were introduced, blood transfusions were widely used for the improvement of platelet counts etc. With recent negative research regarding Erythropoiesis-stimulating agents, blood transfusions will be a choice - seek professional/oncologist opinion. This article from the ACS describes some of the concerns with blood transfusions.

(2009 updated) Ethyol (amifostine) For Injection

(2008) Ethyol (Amifostine) Drug Information: Uses, Side Effects, Drug Interactions and Warnings at RxList

NCI - main site

There are quite a few different clinical trials listed for 'chemotherapy induced neuropathy" - check the search box at the top of the website for clinical trials underway

Clinical Trial SURVEY: Chemotherapy-Induced Peripheral Neuropathy

Phase III Randomized Study of Glutathione for the Prevention of Paclitaxel/Carboplatin-Induced Peripheral Neuropathy in Patients With Ovarian, Fallopi

Phase III Randomized Study of Glutathione for the Prevention of Paclitaxel/Carboplatin-Induced Peripheral Neuropathy in Patients With Ovarian, Fallopian Tube, and/or Primary Peritoneal Carcinoma

Biological Therapies for Cancer: Q & A - National Cancer Institute

What are interleukins?
"Like interferons, interleukins (ILs) are cytokines that occur naturally in the body and can be made in the laboratory. Many interleukins have been identified; interleukin-2 (IL–2 or aldesleukin) has been the most widely studied in cancer treatment. IL–2 stimulates the growth and activity of many immune cells, such as lymphocytes, that can destroy cancer cells. The FDA has approved IL–2 for the treatment of metastatic kidney cancer and metastatic melanoma.
Researchers continue to study the benefits of interleukins to treat a number of other cancers, including leukemia, lymphoma, and brain, colorectal, ovarian, breast, and prostate cancers."

A phase II trial of intraperitoneal interleukin-2 in patients with platinum-resistant or platinum-refractory ovarian cancer

Treatment of disseminated ovarian cancer using nonviral interleukin-12 gene therapy delivered intraperitoneally. Jason G. Fewell. 2009; The Journal of Gene Medicine - Wiley InterScience

Molecular Cancer | Full text | Methylation and protein expression of DNA repair genes: association with chemotherapy exposure and survival in sporadic ovarian and peritoneal carcinomas

CA-125 Response Patterns in Patients With Recurrent Ovarian Cancer Treated With Pegylated Liposomal Doxorubicin (PLD)

Conclusions: "Our ROC analysis did not demonstrate any reliable CA-125 cutoff on response. Discontinuation of the therapy before cycle 3 may exclude some patients who will benefit from PLD."

Five emotions you never knew you had - life - 13 January 2010 - New Scientist

"CAN you name the six basic emotions? Take a straw poll of your friends and we guarantee that you will find no consensus. Yet psychologists are unequivocal: joy, sadness, anger, fear, surprise and disgust...."