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Sunday, November 23, 2008

The Role of Antioxidants and Vitamin A in Ovarian Cancer: Results From the Women's Health Initiative - Nutrition and Cancer



The Role of Antioxidants and Vitamin A in Ovarian Cancer: Results From the Women's Health Initiative - Nutrition and Cancer

"The results from this prospective study of well-nourished, postmenopausal women suggest that intake of dietary antioxidants, carotenoids, and vitamin A are not associated with a reduction in ovarian cancer risk."

Significance of preoperative serum CA-125 levels in the prediction of lymph node metastasis in epithelial ovarian cancer - Acta Obstetricia et Gynecologica Scandinavica



Significance of preoperative serum CA-125 levels in the prediction of lymph node metastasis in epithelial ovarian cancer - Acta Obstetricia et Gynecologica Scandinavica

Uptake of clinical genetic testing for ovarian cancer in Ontario: a population based study



Uptake of clinical genetic testing for ovarian can...[Gynecol Oncol. 2008] - PubMed Result:

"CONCLUSIONS: Genetic testing is available in Ontario to all women with invasive ovarian cancer. However, only a small proportion of women are being referred for testing. This study suggests that increased public awareness directed at physicians and at women with cancer may expand the use of genetic testing."

ICES - search results "ovarian"



1 Health care delivery in Canada and the United States: are there relevant differences in health care outcomes? 5% Investigative Reports September, 2003
At a Glance
2 At A Glance - October 2008 39% At a Glance October, 2008
Journal Publications
3 Outcomes in surgery for ovarian cancer 12% Journal Publications September, 2003
4 Surgical outcomes in women with ovarian cancer 10% Journal Publications October, 2008
Other
5 Chapter 7: Surgery for Ovarian Cancer 100% Other November, 2008
6 Egg race 16% Other April, 2006
7 More than skin deep 12% Other December, 2003
8 Overview 3% Other November, 2008
9 Technical Appendix (abbreviated version) 2% Other November, 2008
10 Chapter 1: Introduction 2% Other November, 2008
11 Chapter 10: Reflections and Recommendations 2% Other November, 2008
12 HC 2008 - Urbach - Cancer surgery services 2% Other February, 2008

Cancer Surgery in Ontario, Chapter 7, Surgery for Ovarian Cancer 2008 December report




Cancer Surgery in Ontario, Chapter 7, Surgery for Ovarian Cancer.pdf (application/pdf Object)

Implications:

 More research is needed to better
understand why the use of cancer
staging procedures—such as
omentectomy and lymph node
excision—varied among women in
the study cohort who underwent
surgery for ovarian cancer.

 Plans for expanding surgical services
related to the treatment of ovarian
cancer in Ontario should factor in the
existing referral patterns among Local
Health Integration Networks (LHINs).

 There are relatively few gynecologic
oncologists in Ontario; these subspecialists
provide care to a large
number of women with ovarian cancer.
Further evaluation is required—both
in terms of the role of gynecologic
oncologists in treating women with
ovarian cancer, and also whether the
supply of these specialists will be
sufficient to meet future demand.

Findings

While the incidence of ovarian cancer among Ontario women increased with age in 2003/04, the probability of surgical treatment decreased. About three-quarters (73 percent) of women in the Overall Ovarian Cancer Cohort underwent a surgical procedure related to the diagnosis and treatment of their disease.

• There was no clear relationship between women’s socioeconomic status and whether they had surgery for ovarian cancer. However, those living in regions with the lowest neighbourhood income were less likely than all others to have ovarian cancer-related surgery. (duh?)


• Rates of ovarian cancer-related surgery ranged across Local Health Integration Networks (LHINs) of patient residence—from a low of 58 percent among women living in the North West LHIN to a high of 88 percent among those residing in the Erie St. Clair LHIN.

Lymph node excision was done in just eight percent of women with ovarian cancer


During the study period, gynecologic oncologists comprised about seven percent of all physicians performing ovarian cancer
surgery in Ontario. Yet these sub-specialists performed nearly half (49) percent of all the surgeries among women in the
Ovarian Cancer Surgery Cohort.

Obstetrician/gynecologists performed 40 percent of surgeries on women in this study cohort; the remaining 12 percent of
procedures were done by physicians with other specialties.

Gynecologic oncologists were more likely than obstetrician/gynecologists to perform omentectomy (70 percent vs. 44 percent respectively) and lymph node excision (13 percent vs. six percent





Canadian Medicine: New study adds weight to call for boys to get HPV vaccine too



Canadian Medicine: New study adds weight to call for boys to get HPV vaccine too

"The study’s failure to demonstrate the vaccine’s effect on cancer is a function of the same problem that some critics of the HPV vaccine identified in the trials on girls: the trials’ follow-up periods aren’t long enough to determine whether there will actually be a drop in cancers, and, if so, how long the vaccine’s protection will last."

Note: nor long-term side effects

OVARIAN CANCER and US: Commentary: Hormone Receptor Testing in Breast Cancer: A Distress Signal from Canada




Commentary: Hormone Receptor Testing in Breast Cancer: A Distress Signal from Canada



Commentary: Hormone Receptor Testing in Breast Cancer: A Distress Signal from Canada -- Allred 13 (11): 1134 -- The Oncologist

Note: this response addresses the clinical aspects but not the political landscape and lack of transparency.

original article:

Breast Cancer Testing Scandal Shines Spotlight on Black Box of Clinical Laboratory Testing

http://jnci.oxfordjournals.org/cgi/content/full/100/12/836?ijkey=bfa78dfa42fd694d7cd597c944b59f7b421076d4&keytype2=tf_ipsecsha