Screening for Lynch syndrome and referral to clinical genetics .... UK

open access
 Screening for Lynch syndrome and referral to clinical genetics by selective mismatch repair protein immunohistochemistry testing: an audit and cost analysis
 

 Take home messages

• Lynch syndrome (LS) screening is currently fragmented and inconsistent in the UK.
• Reflex mismatch repair immunohistochemistry (MMR IHC) on all colorectal cancer (CRC) is now recommended by the Royal College of Pathologists, but MMR IHC status remains a non-core item for all CRCs due to resource implications.
• LS screening through selective MMR IHC model performed for prognostication in stage II CRC can be implemented when funding is limited, especially when expenditure has to be justified by impact on oncological decisions.