OVARIAN CANCER and US: Anaphylactic reactions

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Showing posts with label Anaphylactic reactions. Show all posts
Showing posts with label Anaphylactic reactions. Show all posts

Sunday, June 12, 2011

abstract: Description of anaphylactic reactions to paclitaxel and docetaxel reported to the FDA, with a focus on the role of premedication



Purpose: Anaphylactic reactions (ARs) have been frequently reported with taxanes. The authors' purpose was to summarize published case reports and describe ARs from taxanes reported to the Food and Drug Administration (FDA) with a focus on use of package insert-specified prophylactic premedications (PPMs).

Methods: The authors searched PubMed for the relevant literature.............

Conclusions: Mortality was reported in more docetaxel ARs than paclitaxel. Documented use of PPMs did not significantly impact mortality from ARs with docetaxel, but was associated with significantly lower mortality from ARs with paclitaxel.