May 7th: The connection between genes and colon cancer (Lynch Syndrome/FAP) - MD Anderson Cancer Center - audio/ iTunes

The connection between genes and colon cancer - MD Anderson Cancer Center

Cancer Newsline - 05/07/2012

About 20% of colon cancer cases are related to a strong family history of colon cancer. Eduardo Vilar-Sanchez, M.D., Ph.D., Assistant Professor in the Department of Clinical Cancer Prevention at The University of Texas MD Anderson Cancer Center, focuses his discussion on the main types of genetic colon cancers including hereditary nonpolyposis colorectal cancer syndrome or HNPCC (also called Lynch syndrome) and familial adenomatous polyposis (FAP).

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abstract: Ovarian steroid cell tumor with biallelic adenomatous polyposis coli inactivation in a patient with familial adenomatous polyposis (FAP)

"Our findings provide the first evidence that ovarian steroid cell tumors may be an extracolonic manifestation of FAP (familial adenomatous polyposis - colorectal cancer syndrome) and implicate β-catenin activation as an oncogenic mechanism in ovarian steroid cell tumorigenesis."