short abstract: Gynecological cancer: True progress in ovarian cancer or just the tip of the iceberg?

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 Gynecological cancer: True progress in ovarian cancer or just the tip of the iceberg?

Lisa Hutchinson

"Abstract

Development of malignant ascites is common in patients with ovarian cancer, and few therapeutic options exist for women with ascites whose tumors become resistant to chemotherapy. Furthermore, in such patients symptom palliation options are limited, and the few available treatments are unpleasant and can result in the need for paracentesis."

Targeting annexin A4 to counteract chemoresistance in clear cell carcinoma of the ovary

Take home message: Annexin A4 enhances cancer cell chemoresistance and is overexpressed in tumors of patients with ovarian CCC. Targeting of annexin A4 may represent a future strategy to counteract resistance to chemotherapy in ovarian CCC.