open access: Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy (Chemobrain)

 Blogger's Note: also refer to previous post regarding chemobrain research in mice, differences in the 2 studies include chemotherapy agents, but, same bottom line results (confirmation of side effects/adverse effects of chemotherapy treatments)

Impaired Cognitive Function and Hippocampal Neurogenesis following Cancer Chemotherapy


Conclusions (abstract): 
Our results show that chronic treatment with either of two commonly used chemotherapeutic agents impairs cognitive ability and suggest that strategies to prevent or repair disrupted hippocampal neurogenesis may be effective in ameliorating this serious side effect in cancer survivors.

open access: The Effects of Chemotherapy on Cognitive Function in a Mouse Model: A Prospective Study (Chemobrain)

Blogger's Note:  note article for observations regarding duration of chemobrain/MRI imaging

The Effects of Chemotherapy on Cognitive Function in a Mouse Model: A Prospective Study

abstract: Cognitive function and quality of life in ovarian cancer- Gynecologic Oncology (chemobrain)

Objectives

As advances in treatment have prolonged survival for many patients with ovarian cancer, there has been growing interest in assessing the adverse effects of disease and treatment. The aim of this study was to review the literature on cognitive function and quality of life (QOL) in this population.

Results

The small number of studies including formal evaluations of neurocognitive function suggests that many ovarian cancer patients experience cognitive difficulties associated with their disease and treatment. Several studies described declines in self-reported cognitive function that may impact QOL, but the results were not consistent across studies.

---

Highlights

► The literature suggests that many patients with ovarian cancer experience cognitive difficulties associated with their disease and treatment.
► Several studies reported declines in self-reported cognitive function that may impact QOL, but the results were inconsistent across studies.

in research: The Cognitive Effects of Conjugated Equine Estrogens Depend on Whether Menopause Etiology Is Transitional or Surgical -- Endocrinology

Note: abstract only/$$$ full access

"Type of menopause, surgical vs. transitional, impacts cognitive outcome in women. However, whether type of menopause impacts cognitive effects of HT has not been methodically tested in women or an animal model...........That we now show surgical vs. transitional modes of menopause result in disparate cognitive effects of HT has implications for future research and treatments optimizing HT for menopausal women."

New Clinical Trial Studies Effects of Chemotherapy on Ovarian Cancer Patients

visit http://www.cancer.iu.edu/cancer/trials