OVARIAN CANCER and US: dietary interventions

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Showing posts with label dietary interventions. Show all posts
Showing posts with label dietary interventions. Show all posts

Friday, May 11, 2012

paywalled: (re: juice plus) Gynecologic Oncology - A randomized parallel-group dietary study for stages II–IV ovarian cancer survivors



 Blogger's Note: reference prior posting (juice plus) noting that the audio indicated that the study was done on those ovarian cancer survivours without active disease, not indicated in this abstract (defining cancer survivors?); as well, not indicated (needs confirmation) in the audio is that the study size was small at 51 patients

ScienceDirect.com - Gynecologic Oncology - A randomized parallel-group dietary study for stages II–IV ovarian cancer survivors

A randomized parallel-group dietary study for stages II–IV ovarian cancer survivors 



Abstract

Objective

Few studies have examined the dietary habits of ovarian cancer survivors. Therefore, we conducted a study to assess the feasibility and impact of two dietary interventions for ovarian cancer survivors.

Methods

In this randomized, parallel-group study, 51 women (mean age, 53 years) diagnosed with stages II–IV ovarian cancer were recruited and randomly assigned to a low fat, high fiber (LFHF) diet or a modified National Cancer Institute diet supplemented with a soy-based beverage and encapsulated fruit and vegetable juice concentrates (FVJCs). Changes in clinical measures, serum carotenoid and tocopherol levels, dietary intake, anthropometry, and health-related quality of life (HRQOL) were assessed with paired t-tests.

Results

The recruitment rate was 25%, and the retention rate was 75% at 6 months. At baseline, 28% and 45% of women met guidelines for intake of fiber and of fruits and vegetables, respectively. After 6 months, total serum carotenoid levels and α- and β-carotene concentrations were significantly increased in both groups (P < 0.01); however, β-carotene concentrations were increased more in the FVJC group. Serum β-cryptoxanthin levels, fiber intake (+ 5.2 g/day), and daily servings of juice (+ 0.9 servings/day) and vegetables (+ 1.3 servings/day) were all significantly increased in the LFHF group (all P < 0.05). Serum levels of albumin, lutein and zeaxanthin, retinol, and retinyl palmitate were significantly increased in the FVJC group (all P < 0.05). No changes in cancer antigen-125, anthropometry, or HRQOL were observed.

Conclusion

Overall, this study supports the feasibility of designing dietary interventions for stages II–IV ovarian cancer survivors and provides preliminary evidence that a low fat high fiber diet and a diet supplemented with encapsulated FVJC may increase phytonutrients in ovarian cancer survivors.

Highlights

► Many ovarian cancer survivors fail to meet current guidelines for dietary intake.
► A low-fat diet supplemented with encapsulated fruit and vegetable juice concentrates can improve carotenoid levels.
► Encapsulated fruit and vegetable juice concentrates may help bridge the gap between what is consumed and what is needed.