OVARIAN CANCER and US: intratumor

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Showing posts with label intratumor. Show all posts
Showing posts with label intratumor. Show all posts

Wednesday, March 07, 2012

NEJM: Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing — Free Preview



Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing — NEJM

 Conclusions
Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through *Darwinian selection.
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* Synonym(s)
  • Darwinian selection (natural selection)

Definition(s)

Natural evolutionary process that results in the survival of organisms best suited to changing living conditions through the perpetuation of desirable genetic qualities and the elimination of undesirable ones.