Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion Sequencing — NEJM
Conclusions
Intratumor heterogeneity can lead to underestimation of the tumor genomics landscape portrayed from single tumor-biopsy samples and may present major challenges to personalized-medicine and biomarker development. Intratumor heterogeneity, associated with heterogeneous protein function, may foster tumor adaptation and therapeutic failure through *Darwinian selection.
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* Synonym(s)
- Darwinian selection (natural selection)
Definition(s)
- Natural evolutionary process that results in the survival of organisms best suited to changing living conditions through the perpetuation of desirable genetic qualities and the elimination of undesirable ones.
