Introduction
Familial non-syndromic
colorectal cancer (CRC) constitutes one of the most difficult and
diverse patient groups encountered in a genetics clinic, with no
apparent germline mutation, an often-indeterminant mode of inheritance,
and questions arising as to how to manage the probands, and how to
identify which family members are also at risk for CRC........ The clinical significance of HPS is that it is associated with an
increased personal and familial risk of CRC ,
and extra-colonic cancers in the wider family setting .
Conclusion
A
decreased odds for CRC was identified in females with multiple serrated
polyps who currently smoke, independent of age and the presence of a
traditional adenoma. Investigations into the biological basis for these
observations could lead to non-smoking-related therapies being developed
to decrease the risk of CRC and colectomy in these patients.
