Preliminary Session Information | ASCO Annual Meeting

Preliminary Session Information 
 Preliminary session information* provides an outline of the Annual Meeting Program and is organized by day. Session information includes:

• Session titles
• Session dates and times
• Education program faculty

Click each day's link for full details.

Friday, May 31, 2013
Saturday, June 1, 2013
Sunday, June 2, 2013
Monday, June 3, 2013
Tuesday, June 4, 2013
* Information is up to date as of January 28, 2013.

Ovarian cancer among 8005 women from a breast cancer family history clinic: no increased risk of invasive ovarian cancer in families testing negative for BRCA1 and BRCA2

Abstract

Background Mutations in BRCA1/2 genes confer ovarian, alongside breast, cancer risk. We examined the risk of developing ovarian cancer in BRCA1/2-positive families and if this risk is extended to BRCA negative families.

open access: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer : Nature Genetics (technical)

open access

"..... However, on the basis of what is known about the architecture of genetic susceptibility for other cancers, it is probable that many more common susceptibility alleles exist. The discovery of genetic association with ovarian cancer may be enhanced by taking advantage of functional annotation data and the analysis of gene-gene and gene-environment interactions using a genome-wide approach. Continued international efforts are needed to establish new case-control studies, expand existing case-control studies and improve the pathological characterization of the cases in these studies to unravel the inherited genetic basis of the disease. In combination with rarer risk alleles and other risk factors, genetic profiling may provide sufficient discrimination to justify targeted ovarian cancer prevention."

see table 2 for included cell types/risk ratio:   
Table 2: ORs and tests of association by histological subtype and population for the most strongly associated SNPs at 8q21, 10p12 and 17q12

Five genetic variations increase risk of ovarian cancer - DukeHealth.org

Five genetic variations increase risk of ovarian cancer - DukeHealth.org

"...Inherited mutations in the BRCA1 and BRCA2 genes dramatically increase ovarian cancer risk. Genetic testing for BRCA1 and BRCA2 mutations can identify women who would benefit most from surgery to prevent ovarian cancer, but this is relevant to less than 1 percent of the population. Other genetic variants that are more common may also affect ovarian risk. The Ovarian Cancer Association Consortium previously described six such genetic differences and now the COGS project has found five more.....

"..."Because of the large number of study subjects, we were able to determine that some genetic variants were important to specific subgroups of ovarian cancer, suggesting possible differences in the underlying cause of these subtypes," Schildkraut said.....

ASCO Unveils Decision Support System

Article

"...But CancerLinQ, a project of ASCO's Institute for Clinical Excellence, is still in the testing stages. ASCO plans to publish information on the system in coming year, and use knowledge gained to develop the full CancerLinQ system.
"We talk about getting second opinions," Charles Penley, MD, of Tennessee Oncology in Nashville, said. "This will be second opinions times multiples."
Just 3% of cancer patients enter clinical trials -- the main data set oncologists use for evidence-based guidelines. CancerLinQ would tap the remaining 97%, supporters here said.....

Proposal for the Breakdown of Increased Cancer Healthcare Cost and Its Improvement

Abstract

 "Technological progress in the field of cancer treatment can be expected to accelerate in the future, giving hope to such patients. At the same time, there is concern that cancer care will become more expensive. It is indispensable to minimize the economic burden of patients to deliver technological advances in treatment. It is important for the physician engaged in cancer care to recognize the economic burden of patients and to reduce this burden as much as possible. The Cancer Control Act was enacted in 2007 to promote work on cancer control using all the resources of the nation, and this should surely entail financial support. In order to take advantage of innovations in cancer care, reform of the payment system to lighten the economic burden of the patient would be a pressing necessity."

Oncology Nurses' Recognition of Supportive Care Needs and Symptoms of their Patients Undergoing Chemotherapy

Abstract

Objective To assess the accuracy of oncology nurses' recognition of supportive care needs and symptoms of their patients undergoing chemotherapy.

Association of BRCA1/2 mutations with FMR1 genotypes: Effects on menarcheal and menopausal age

Abstract
 

OBJECTIVE:

Female BRCA (breast cancer gene)-1 and BRCA-2 mutations are significantly associated with risk of developing breast and ovarian cancers, in turn, associated with female infertility. BRCA-1 mutations have also been associated with occult primary ovarian insufficiency (OPOI), as have different mutations of the FMR1 gene. We, therefore, hypothesized that FMR1 genotypes may be associated with menarcheal and menopausal ages of BRCA mutation carriers.

3 articles - genome - BRCA1/BRCA2/breast cancer associations in Asians

open access

BRCA1 mutation carriers
BRCA1 mutation carriers are at increased risk for both breast and
ovarian cancers.....

BRCA2 mutation carriers
A previous study from the Consortium of Investigators of Modifiers
of BRCA1/2 (CIMBA) reported a genome-wide association study
(GWAS) for breast cancer risk in BRCA2 mutation carriers (PLoS Genet.
6, e1001183, 2010), identifying only known loci previously associated
with breast cancer risk in the general population. Kenneth Offit and
colleagues now report an extended replication, including genotyping
using the iCOGS array, of 3,881 BRCA2 mutation carriers with breast
cancer and 4,330 without breast cancer from CIMBA...

Breast cancer associations in east Asians
To extend findings of breast cancer association studies that have primarily been conducted in European-ancestry populations, Wei Zheng
and colleagues systematically examined the association of known
breast cancer susceptibility loci in east Asian women....

open access: Risk of breast cancer in Lynch syndrome: a systematic review

open access

Conclusion
 It is premature to provide a definitive answer to whether breast cancer is a Lynch syndrome ancer because of the following limitations. There is only one prospective study demonstrating an elevated risk of breast cancer in Lynch syndrome and further independent evidence is required to confirm the findings. Given the previous epidemiological studies used
different selection methods, subjects and statistical methods, a meta-analysis is not appropriate to generate a pooled estimate for breast cancer risk. Current evidence of the breast cancer risk is mainly from Caucasian populations and therefore may not be applicable
to the other ethnicities or populations, particularly given previous studies have demonstrated that risk of Lynch syndrome cancers vary across populations [77]. Given these limitations
and given breast cancer is relatively common disease in the general population, we recommend that studies to provide more precise estimate of risk will need to utilize large prospective cohort studies with a long follow-up. While current data is inconclusive at a population level, individual tumor testing results suggest that MMR deficiency is involved
with breast cancers in some individuals with Lynch syndrome.

Patient Experiences With Full Electronic Access to Health Records and Clinical Notes Through the My HealtheVet Personal Health Record

Abstract

Conclusions: P
atients and their delegates had predominantly positive experiences with health record transparency and the open sharing of notes and test results. Viewing their records appears to empower patients and enhance their contributions to care, calling into question common provider concerns about the effect of full record access on patient well-being. While shared records may or may not impact overall clinic workload, it is likely to change providers’ work, necessitating new types of skills to communicate and partner with patients.

Number of Cancer Survivors Expected to Increase to 18 Million by 2022 | AACR News

 AACR News
 

• The current number of cancer survivors is 13.7 million.
• The increase is primarily due to aging of the population.
• Survival is not uniform across cancer types.

New Gene Markers Reveal Cancer Risk - ABC News

media

The impact of coffee on health

Abstract

Conclusion

The information gathered in recent years has generated a new concept of coffee, one which does not match the common belief that coffee is mostly harmful. This view is further supported by the discovery of a series of phyto-components with a beneficial profile. Reasonable optimism needs to be tempered, however, by the insufficiency of the clinical data, which in most cases stem from observational studies.

ESMO Debate: Should Neoadjuvant Data Be Used To Speed Drug Approval?

Clinical Oncology News

Reducing work hours for medical interns increases patient 'handoff' risks | e! Science News

escience news

Note: new Wiki gadget added (sidebar)

Wikipedia gadget (searchable)

“How Do I Say This Nicely? Your Oncologist Wasn't Following Guidelines”

Cancer Network

"....The National Comprehensive Cancer Network (NCCN) recommendations for follow-up testing for most diagnoses are easy to support. So when you start seeing a patient for the first time who has been treated elsewhere and the previous oncologist has not followed standard protocol, how do you present this new way of doing things without alienating the patient or sounding critical of the previous doctor?..."

(patents) Health News - You Don't "Own" Your Own Genes

Health News

Robotic surgery safety/marketing concerns in Globe & Times stories

Healthnewsreview

open access: Lynch syndrome related endometrial cancer: clinical significance beyond the endometrium

open access

"....Recently, focus has shifted to LS-related endometrial cancer (EC) as women with LS have a 40-60% chance of presenting with EC as the first clinical manifestation....

"...It is interesting to note that LS-related EC sometimes is accompanied (synchronous, or metachronous) by LS-related ovarian cancer. In fact in LS, the lifetime risk for endometrial cancer is 40-60%, and for ovarian cancer, 9-12% [19]. The latter is usually clear cell carcinoma and can present independently and less frequency [4,20]. Compared to LS-related EC cases, LS-related ovarian cancer tends to have a higher MSH2 mutation rate and occurs in a younger age, average of 45 years old [21]......

Systematic Review of Quality Improvement Interventions Directed at Cancer Specialists

Abstract

Conclusion The published evidence about how to facilitate timely and consistent adoption of new clinical knowledge by cancer specialists into everyday clinical practice is thin. More investment is needed in research about the solution (QIIs) to match the investment in research about the problem (inconsistent/slow adoption of innovative cancer treatments). 

Association of Primary Breast Cancer of the Vulva With Hereditary Breast and Ovarian Cancer

Sign In (no abstract/requires paid subscription)

Outcome mapping for health system integration (Ontario/LHIN as an example)

Open access

Abstract: 
Health systems around the world are implementing integrated care strategies to improve quality, reduce or maintain costs, and improve the patient experience. Yet few practical tools exist to aid leaders and managers in building the prerequisites to integrated care, namely a shared vision, clear roles and responsibilities, and a common understanding of how the vision will be realized. Outcome mapping may facilitate stakeholder alignment on the vision, roles, and processes of integrated care delivery via participative and focused dialogue among diverse stakeholders on desired outcomes and enabling actions......

Patient-Oncologist Alliance, Psychosocial Well-Being, and Treatment Adherence Among Young Adults With Advanced Cancer

Abstract

Conclusion By developing a strong alliance, oncologists may enhance psychosocial well-being and increase treatment adherence in young adult patients with advanced cancer.